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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

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They signal actively when GTP is bound and signaling terminates when their intrinsic GTPase converts GTP to GDP

The peptides don't compete or interfere with each other