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Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is expected to be regained over the next 5 years [4, 5]

IGF-1 promotes new nerve growth in the brain and has been linked to increased cognitive performance as well as subjective feelings of youth and well-being

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doi: 10.1038/s41467-024-46829-0 34 MirjiGWorthABhatSAEl SayedMKannanTGoldmanARet al