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The cells were then stained with propidium iodide (PI) and cell death was verified by flow cytometry (FACScan, Becton-Dickinson, Mississauga, ON, Canada)

In response to LPS, there was significant NF-B signal transduction pathway enrichment in LKO cholangiocytes with increases in several chemokines such as Cxcl2 (8-fold increase) and Cxcl5 (128-fold increase) as well as the proposed BA diagnostic chemokine Mmp7 (9-fold increase)

Interestingly, there is a phenomenon known as the obesity paradox where having a higher Body Mass Index (BMI) in late life is associated with a lower risk of dementia, despite midlife obesity being a significant risk factor

Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues