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Further studies showed that CDC appears to be a more prominent effector mechanism for daratumumab [22, 28], with evidence suggesting that isatuximab induces CDC only in the presence of high CD38 receptor density [24, 32]

It is estimated that 70% of obese individuals have fewer receptors for dopamine compared to normal weight individuals

The endpoint outcome, rather than any safety signal, is what redirected the program

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Besides the medical condition it is advised for, the route of administration also plays an important role in determining the correct drug dosage