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It must be acknowledged that each patients health conditions, medications profile, and impact of medications might be different, and cognizance should be taken of the seriousness of the medical emergency, the potential causal relationship with the psychotropic medications, and the final necessity of the medication

In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51