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Nonetheless, it is very likely that any effects of dietary heme are limited to the gastrointestinal tract

Similar observations were noted in later human studies [56, 57], with the peak serum TMAO observed within hours following oral administration of the tracer [56]

A further feature of interest is that the last three enzymes in the cycle with a specificity for long-chain fatty acids constitute a trifunctional enzyme complex on the inner mitochondrial membrane

Dysregulated BA metabolism is an important indicator in the pathology of MAFLD, which directly affects lipid metabolism, immune environment, and intestinal bacteria (Yu et al., 2018)