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Studies in multiple model organisms have demonstrated that this age-related NAD+ decline correlates with mitochondrial dysfunction, impaired DNA repair capacity, and the onset of numerous age-associated pathologies

Barzinmehr, H., Mirza-Aghayan, M

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In this regard, it has been reported that H 2 O 2 induces autophagic cell death in glioma cells after treatment with the polycyclic ammonium ion sanguinarine, which increases electron leakage from mitochondria and induces NOXs 119