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The I148M variant disrupts the phospholipase activity of patatin-like phospholipase domain-containing 3 (PNPLA3), a triglyceride lipase, thereby interfering with lipid catabolism and promoting hepatic fat accumulation to increase the risk of liver-related mortality in patients with NAFLD [17, 18]

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Skin Brightening and Whitening: Inhibits melanin production at the source, gradually lightening the complexion and delivering a uniform, radiant skin tone across the entire body

Gray literature was not actively sought but considered if eligibility criteria were met

Other limitations include the fact that the in vitro granuloma model used is not an exact replication of in vivo granulomas which have a more complex and dynamic environment containing other cells like fibroblasts, collagen matrix, and other white blood cells