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10.1146/annurev.immunol.26.021607.090357 102 MalmstrmV.CatrinaA

In addition, our IGF1 dose-response experiments show that IGF1R exhibits slightly lower activity in response to very high concentrations of IGF1 (Supplementary Fig

15 Damage-associated molecular pattern (DAMP) species released into the circulation, such as nuclear fragments and mitochondrial DNA (mtDNA), appear to recruit inflammatory cells via the innate immune system as the livers attempt to remove necrotic cell debris and promote the livers recovery phase