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Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance

The activity of the enzyme complex in endothelial and smooth muscle cells is increased upon stimulation with angiotensin II (ATII)

Stafford P, Abdelwahab MG, Kim DY, Preul MC, Rho JM, Scheck AC

Metabolic regulation of protein homeostasis in ageing Protein quality control in living organisms is essential for the maintenance of cell viability that maintains a relatively balanced state of the proteome in regards to synthesis, folding and unfolding, modification, trafficking, and degradation of specific proteins