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HF, XL and DF were responsible for project administration

Both the Wegovy pill and the Wegovy pen contain the same active ingredient, semaglutide, and are FDA-approved for weight management

Abbreviations CVD: Cardiovascular disease HF: Heart failure HFrEF: Heart failure with reduced ejection fraction IV: Intravenous ID: Iron deficiency TSAT: Transferrin saturation FCM: Ferric carboxymaltose DCYTB: Duodenal cytochrome B CRT: Cardiac resynchronization therapy CMR: Cardiac magnetic resonance ROS: Reactive oxygen species ATP: Adenosine triphosphate Fe: Iron FPN: Ferroportin sTfR: Soluble transferrin receptor TIBC: Total iron-binding capacity HIF: Hypoxia-inducible factor IL: Interleukin eNOS: Endothelial nitric oxide synthase HFE: Hemochromatosis gene AHA: American Heart Association ACC: American College of Cardiology HFSA: Heart Failure Society of America ESKD: End-stage kidney disease References WHO

Conclusion In conclusion, DP accelerates DFU wound healing by activating the Nrf2 signaling pathway, thereby inhibiting ferroptosis

Case 5 A 15-year-old female patient presented with 6 days history of difficulty in walking with feeling of cotton wool-like sensation over sole while walking