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doi: 10.1517/13543776.2015.1056737

While the role of leptin resistance in ICU-AW has not been thoroughly explored, several features common to critical illnesssuch as systemic inflammation, metabolic dysregulation, and elevated leptin levelsmay synergistically facilitate the emergence of a leptin-resistant state

doi: 10.1111/j.1749-6632.1990.tb16169.x

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Further studies include REDEFINE 3 (heart benefits vs placebo in adults with heart disease) and REDEFINE 4 (84-week head-to-head vs tirzepatide 15 mg)