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Growing evidence from randomized clinical trials (RCTs) and mechanistic studies indicates that specific microbial signaturessuch as enrichment of taxa like Lachnoclostridium and Roseburia inulinivorans and associated BA profiles, including elevated levels of ursodeoxycholic acid (UDCA), taurolithocholic acid (TLCA), and chenodeoxycholic acid (CDCA), are consistently correlated with favorable outcomes in hepatocellular carcinoma (HCC), non-small cell lung cancer (NSCLC), and esophageal cancer (119, 148)

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