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AOP Development Strategy Context This AOP was developed for the project "CHRONIC TOXICITY OF PESTICIDES IN DRINKING WATER IN PARABA (TRIGGER): IDENTIFYING THE TRIGGERS OF A SILENT EPIDEMIC," financed by the "Fundao de Apoio Pesquisa do Estado da Paraba (FAPESQ-PB)." The project aims to understand how oxidative stress and reproductive toxicity can be triggered in animals by aquatic pollutants, such as atrazine Strategy The first step in developing this AOP was to conduct a literature review to gather toxicological data on the herbicide atrazine's impact on aquatic vertebrates in relation to oxidative stress and reproductive toxicity

More than 4 million adults aged 18 and older have been diagnosed with liver disease, with many more still undiagnosed

Andreeff M , Bartal A, Feit C, Hirshaut Y

doi: 10.1054/arth.2001.23716