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Semaglutide and tirzepatide are GLP-1 receptor agonists

Some people struggle with weight loss because of underlying B12 deficiencies caused by diet or absorption issues

Oral treatment of vitamin B12 deficiency

Patients who do respond meaningfully to the combination may continue cycling AOD-9604 in defined patterns (typically with the 4 to 8 week break between cycles) for as long as the response remains clinically useful

Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring