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When unfolded or incorrectly folded proteins are present in the cell, ERS is activated to diminish the concentration of these abnormal proteins and prevent their aggregation

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For example, recent studies have shown that perturbation of COQ2, a key enzyme responsible for coupling the isoprenoid tail to the quinone head group, increases ferroptosis sensitivity, and thus targeting COQ2 enhances ferroptotic vulnerability in multiple myeloma cells 35

this process is impaired in diabetes, contributing to diabetic complications (Yapislar 2012)