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Convenience should not be the only factor

In a recent study of 275 PD patients and 144 controls, as well as atypical PD cohorts, neuronal EVs were isolated using L1CAM immunocapture, followed by mass spectrometry or electrochemiluminescence to measure proteins including alpha-synuclein and clusterin 106 : Compared with controls and other neurodegenerative conditions including MSA, levels of mean neuron-derived exosomal alpha-synuclein were two-fold higher in clinical PD and prodromal PD, with an AUC of 0.86 for separating patients with PD from controls 106

Moreover, CLP increased the systemic levels of NO (Figure 2H), IL-1 (Figure 2I), and TNF- (Figure 2J)

10.3390/toxins10010025 52 LinL.FuP.ChenN.GaoN.CaoQ.YueK.et al (2022)

DiNunzio JC, Brough C, Hughey JR, Miller DA, Williams RO, McGinity JW