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ABC transporter is responsible for accumulation and transmembrane transport of secondary metabolites and the most upregulated DEGs, as shown in Table 1 (3.4-fold) (Theodoulou and Kerr, 2015)

Therefore, it is critical to scientifically examine how diet can serve as a molecular therapeutic tool in cancer treatments as part of a personalized diet for patients

Nagano et al., 2002)

The peptide increases survival of enteric neurons, enhances enteric glial cell proliferation, and modulates enteric serotonin release

Future studies should aim to delineate the immune synergism between ICIs and concomitant medications in order to refine clinical drug management, improve early risk identification, and prevent severe adverse reactions