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Keywords Penicillamine Trade Names: Cuprimine, Depen Drug Class: Heavy metal chelator Mechanism of Action: copper chelator

As such, caseating granulomas with central necrosis must be considered infections, until serious evidence eliminates the diagnosis

284 In addition, PD-L1 upregulation was observed in tumor cells after V-9302 treatment, and the combination of V-9302 and anti-PD-1 antibody showed greater anti-tumor efficacy than either drug alone