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It can take up to 5 years before a deficiency manifests itself clinically, and NPs should be aware and alert to the possibility of B12 deficiency in their patients on prolonged metformin

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doi: 10.5664/jcsm.7936

Neurogenic bladder dysfunction refers to any disturbance of bladder function due to impaired neural control and needs to be distinguished from non-neurogenic bladder disorders, especially in elderly individuals