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During this response, stress hormones like cortisol and adrenaline are released, which can cause a temporary rise in blood pressure

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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)

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Unlike semaglutide, tirzepatide targets both GLP-1 and GIP (gastric inhibitory polypeptide) receptors, enhancing fat metabolism and insulin sensitivity