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GI cancers arise from complex mechanisms involving chronic inflammation, genetic mutations, and disrupted signaling pathways that promote uncontrolled cell growth and metastasis

2011;3:87ra53 Alhakamy NA, Alamoudi AJ, Asfour HZ, Ahmed OAA, Abdel-Naim AB, Aboubakr EM

It has been reported that attaching the m7G with another m7G via tetraphosphate (m7Gppppm7G) increases the affinity of the mRNA with elF4E compared to the natural analogue, thereby increasing the translation by two fold [104]

doi: 10.3390/molecules23010168 120

However, researchers emphasize that careful consideration of causality relationships and genetic factors remains essential for proper scientific interpretation