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According to the National Institute on Drug Abuse (NIDA), persistent cravings are a hallmark of substance use disorder and indicate a growing dependence on the medication

These undesirable consequences are influenced by the type and dose of xenobiotic and show considerable species differences in susceptibility and severity that need to be understood for assessing the potential effects on human health from similar exposures to specific xenobiotics

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Currently, substantial progress has been made in the development of therapies targeting the core pathology of AD, focusing mainly on A and tau proteins (Huimin et al., 2023