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doi: 10.1016/j.jconrel.2025.113888 91 KnezevicNNCandidoKDVlaeyenJWSVan ZundertJCohenSP

The pathogenesis of COPD involves several pathogenetic processes including oxidative stress, inflammation, protease/antiprotease imbalance, apoptosis, and cellular senescence [43, 58] (Fig

(PubMed) Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S

Nat Med 29(6):1336-1337, 2023

CAPE blocks IKK phosphorylation, preventing NF-B nuclear translocation and cytokine expression ( Experimental studies support honeys suppression of NF-B and MAPK signaling in vitro