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Description

Careful identification of the individual oxidant and antioxidant moieties and their behaviors allows for a better understanding of the mechanics of OS (121, 122)

Hemil and de Man 2021

While the PPP does involve oxidation of glucose, its primary role is anabolic rather than catabolic, using the energy stored in NADPH to synthesize large, complex molecules from small precursors

452 These STAT1 heterodimers bind to IRF1 to form a complex, 473 which then translocates to the nucleus and binds to the IRF1 response element (IRE), modulating the transcription of PD-L1 genes and upregulating PD-L1 expression