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Atypical ubiquitination and Parkinsons disease

Of relevance, HO-1 appears overexpressed both in brain and plasma of Parkinson patients and its upregulation by astrocytes promotes the -synuclein production, with consequent brain impairment and toxicity (115, 118)

Alejandro Donoso y el Encargado de las Reuniones Clnicas es el Dr

When NCOA4 expression is upregulated, it recognizes and binds to ferritin heavy chain 1 (FTH1) and mitochondrial ferritin (FTMT), interacting with autophagy-related factors and primary autophagosomes to form autophagosomes for lysosomal degradation, thereby releasing large amounts of Fe 2+ and forming the LIP