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Description

Mechanistically, TMAO promotes angiotensin (Ang) II-induced vasoconstriction, thereby facilitating the development of Ang II-induced hypertension [69]

Published IC50 data from cell-based assays places potency far below botulinum toxin A

10.1113/jphysiol.2004.063388 J

Yoshino et al

The MS-CETSA technique exploits altered thermal stability and solubility of ligand-bound proteins, which are then quantified at proteome-wide level using protein mass spectrometry to identify putative targets