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S1PR2, located both in the liver and in the brain, activates the ERK and AKT pathways that regulate cell survival, inflammation, and stress response in the CNS

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Additional causes of liver damage include alcoholic liver damage, nonalcoholic fatty liver disease (NAFLD) due to fat accumulation, and drug-induced liver injury (Figure 1)

Research into cytokine modulation, oxidative stress responses, and cellular signalling cascades has drawn on this peptide as a research tool, particularly in studies examining how certain peptide sequences interact with inflammation-related molecular pathways in controlled in vitro environments

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