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Dysregulation of this metabolic checkpoint could lead to either excessive synaptic loss or the survival of damaged neurons, contributing to neurodevelopmental or neurodegenerative pathologies

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6a, b) and western blot analysis (Fig

Introduction Glutathione S -transferases (GSTs) are a family of enzymes that conjugate reduced glutathione (GSH) to target molecules in the phase II detoxification of xenobiotic metabolism ( Here we examined the mechanisms of how GSTM1 regulates astrocyte transcriptional program in response to pro-inflammatory signaling and further addressed the impact of GSTM1 loss-of-function on neurons during acute brain inflammation following a systemic injection of lipopolysaccharides (LPS)