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Mesoporous silica nanoparticles in biomedical applications

DIA MS2 scans were acquired in the Astral mass analyser with a 3 ms maximum injection time using a variable windowing scheme, using 2 Da windows from 380 to 680 m/z , 4 Da windows from 680 to 800 m/z and 8 Da windows from 800 to 980 m/z

Since ECM dysregulation is often reported as the key step in the invasion-migration cascade, a comprehensive study of tumor cell EVs and their interactions with the ECM complex will help determine the drivers of distant organ activation and subsequent tumor invasion (Kaushik et al., 2016)