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9 Animal experiments have shown that dual ALDH2 knockout in the gut and liver synergistically reduces alcohol preference and intake relative to knockout in one of these organs

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28 It has been reported that transformation of SAM to SAH determined the transsulfuration pathway activity, inducible of which contributed to cellular cysteine pool and promoted cancer cell growth upon cysteine restriction

The reduced form is the active antioxidant

doi: 10.1016/j.jchromb.2009.05.020