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We did this experiment on the four clock neuron clusters from the adult brain marked by R6-Gal4 (including s-LNvs cluster neurons), C929-Gal4 (including l-LNvs cluster neurons), R18H11-Gal4 (including DN1s cluster neurons), and DVpdf-Gal4 , pdf-Gal80 (including LNds cluster neurons) (Fig 2A)

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MG98 is an antisense oligonucleotide that targets 3UTR of DNMT1 and induces demethylation in vitro and in vivo [96]

Autologous Transplant: Following chemotherapy or radiation therapy the patients cells are extracted processed and then reintroduced into the body in an autologous transplant