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57 MMPs also play a role in vascular remodelling by modulating the migration and proliferation of smooth muscle cells and endothelial cells and mediating the release of the smooth muscle cell mitogens and growth factors, increasing the risk of COPD pulmonary hypertension

In brief, primary CD8 + T cells were isolated from the blood of anonymous donors (Stanford Blood Center) by negative selection (StemCell Technologies, 17953)

Critically, none of the peptides in this combination contain cysteine or methionine residuesthe primary targets of copper-catalyzed oxidationmaking the most concerning degradation pathway chemically impossible for this specific blend

J Clin Microbiol 53:34013404

Curve fitting for enzyme kinetics and other statistical analyses for peptide binding and polarization experiments are detailed in the appropriate methods