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BV-2 cells were treated for 15 min with various concentrations (0.02, 0.5, 2 mol/L) of the selective TRPV1 antagonist BCTC to block signaling through this receptor prior to the addition of p-aminophenol or AM404

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Aspartame administered by transplacental and perinatal exposure followed by oral administration (feed) in male Sprague-Dawley rats caused malignant schwannoma and in female rats aspartame caused mammary gland carcinoma, and renal pelvis papilloma

Neuropeptides and derivatives thereof: peptide YY (PYY), neuropeptide Y (NPY), pancreatic polypeptide (PP), neurokinin A, neurokinin B, endorphin, enkephalin, met-enkephalin (Tyr-Gly-Gly-Phe-Met), dalargin, loperamide, endomorphin-1 and 2, neurotensin, neuromedin K, neuromedin L, calcitonin related peptide (CGRP), endothelin, ANP ("actrial natriuretic peptide"), BNP ("brain natriuretic peptide"), CNP (C-type natriuretic peptide"), and PACAP ("pituitary adenylate cyclase activating peptide"), TAPP (H-Tyr-D-Ala-Phe-Phe-NH2), senktide (sequence DFFGLM with modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)

It has been indicated that the mutation of the gene triggers the inflammatory response and further exacerbates the gastric ulcers (Sheh et al., 2010)