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(I) The relevant mechanisms involved in each step of the intracellular GSH exhaustion process need to be further explored, and the biological effect of cancer cells after GSH depletion remains to be elucidated

Meanwhile, the levels of GPX4 and its cofactor GSH decreased, while the markers of labile iron content (Fe 2+ ) and lipid peroxidation product MDA increased significantly

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Although prolonged GSH depletion induced triglyceride depletion and reduced epididymal adipose tissue in mice, it induced a sex-dependent requirement of NRF2 expression in the liver

Glutathione is found in cells throughout the body and comprises three amino acids: glycine, cysteine, and glutamic acid