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Lv-TpNOX depleted cytosolic NADPH content in normal cultured HAECs and prevented NADPH elevation in Ang II-treated HAECs with or without Lv-G6PD (Fig

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Upregulated expression of PGC-1, a marker of mitochondrial biogenesis, has been observed in fibroblasts from late-stage FRDA patients, suggesting accelerated mitochondrial biogenesis [188]