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10.1038/s41586-020-2012-7 19

The duration of follow-up in most studies ranged from 3 to 12 months

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mtDNA can activate innate immune sensors such as Toll-like receptor 9 (TLR9) and the cytosolic cGAS-STING pathway in various cardiac cells, fueling a feedforward loop of interferon and cytokine production (92)

Specialist supplements such as DHEA, high-dose myo-inositol, or NAC may be appropriate, but should be discussed with a clinician particularly DHEA, which is only indicated for diminished ovarian reserve