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doi: 10.3389/fmicb.2022.845173 Received 29 December 2021 Accepted 14 March 2022 Published 25 April 2022 Volume 13 - 2022 Edited by Yuji Morita, Meiji Pharmaceutical University, Japan Reviewed by Volker Behrends, University of Roehampton London, United Kingdom

Prior to use, researchers reconstitute the material into solution using standard laboratory procedures

The extant body of scholarly work indicates that these botanical supplements manifest their antidepressant properties not merely through straightforward pharmacodynamic mechanisms but rather via extensive modulation of neurochemical networks at a systemic level

This paucity of high-quality, targeted clinical trials prevents establishing standardized synbiotic protocols, reliable dosing regimens, or definitive medical recommendations for therapeutic gut-brain axis interventions in AD management [114]