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NAFLD is associated with increased TCA flux in the liver (Rauckhorst et al., 2017, Satapati et al., 2012, Sunny et al., 2011), raising the question of whether NAFLD progression is accelerated by ER stress arising from this increased flux, and whether diminished hepatic TCA flux in mice lacking MPC activity protects the liver at least in part by alleviating or preventing ER stress

Experimental evidence suggests that bicarbonate may interfere with fibrin clot formation by disrupting the conversion of fibrinogen to fibrin in coagulation studies