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PPAR- plays a pivotal role in glucose and lipid metabolism and overall homeostasis

The shared mechanism between TRE and traditional CR is calorie restriction, which activates metabolic repair pathways (e.g., the fasting physiology)

This timing helps sustain a steady supply of vital nutrients since the benefits can last from a few days up to a couple of weeks, depending on individual metabolism and the specific IV formula used

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[DOI] [PubMed] [Google Scholar] Martin-Loeches I., Lisboa T., Rhodes A., Moreno R.P., Silva E., Sprung C., Chiche J.D., Barahona D., Villabon M., Balasini C., Pearse R.M., Matos R., Rello J., ESICM H1N1 Registry Contributors Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection