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Acknowledgements This work was supported by Chang Gung Memorial Hospital [CMRPG391311, CMRPG3A1131, CMRPG3H0611 and Grants CIRPD1D0071-3

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For example, GLP-1 receptor agonists such as semaglutide and tirzepatide improve insulin sensitivity, lower A1c, and reduce visceral fat while preserving lean muscle mass one of the most critical tissues for long-term metabolic health

Think of peptides as creating the optimal internal environment for healing, while physical therapy provides the necessary mechanical stimulus to guide that healing in the right direction

This connection helps explain why inflammatory gastrointestinal conditions are sometimes associated with metabolic disturbances