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Table 2 includes orthologs of proteins and polypeptide molecules or portions thereof comprising nucleic acid sequences having at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99.5% or more identity over their entire length to nucleic acid sequences of any of the publicly available sequences listed in table 2

In addition, the tricarboxylic acid cycle or electron transfer chain in the mitochondria can promote lipid ROS accumulation and is involved in cysteine-deprivation-induced ferroptosis [18]

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Incubation of inhibitor 2 under the biochemical assay conditions with TGR and with or without NADPH resulted in no formation of derivatives of 2