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Nutlin-3, an inhibitor of murine double minute 2 (MDM2), enhances p53 stability and preserves intracellular GSH levels via a p53-dependent mechanism, allowing cell survival under cystine-deprived conditions (98)

Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig

The presence of an electrophilic hydroxyl group on the chroman ring, allows Vitamin E to be a strong antioxidant

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