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Neomycin, colchicine, para-aminosalicylic acid, or excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. Chloramphenicol and other drugs having bone marrow suppressant properties may cause a lack of therapeutic response to vitamin B12

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Prescription Medications If lifestyle modifications, self-care measures, and other treatments like supplements do not relieve RLS symptoms, your healthcare provider may prescribe one or more of the following medications to treat severe RLS symptoms: Dopaminergic medications that increase dopamine levels in the brain

[DOI] [PubMed] [Google Scholar] 137.Veeranki S.P., Gebretsadik T., Mitchel E.F., Tylavsky F.A., Hartert T.V., Cooper W.O., Dupont W.D., Dorris S.L., Hartman T.J., Carroll K.N