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In conclusion, the persistent presence of UPEC in bladder epithelial cells involves ferritinophagy, which promotes bladder epithelial cell death, exacerbating the severity of urinary tract infections

doi: 10.1186/s42523-021-00159-4 159 LiZ.TranN

Inducers mainly include (1) small molecules and drug inducers targeting iron metabolism: such as Erastin, Temozolomide (TMZ), and small molecules like MMRi62

Uncontrollable necrosis has been considered an ACD [60]