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Glutathione in Health and Disease: Pharmacotherapeutic Issues

10.1016/j.pbb.2011.09.002 103 ZhangH.JiaH.LiuJ.AoN.YanB.ShenW.et al

Elevated NAD+ activates sirtuins (SIRT1, SIRT3)

McLaughlin, L

shortens action potential duration Class IC : Exerts strong sodium channel blockade with minimal impact on action potential duration While all Class I agents share a common mechanismsodium channel inhibitiontheir differing electrophysiologic profiles result in varied clinical applications and risks (11)