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With new clinical trials of APR-246 commencing in multiple tumour streams 2 , our discovery of SLC7A11 expression as a robust companion biomarker, in addition to mut-p53 status, for APR-246, may facilitate selection and enrichment of patients with mut-p53 tumours who are most likely to respond to APR-246 therapy

Lyophilized powder has a shelf life of several years when stored correctly under refrigeration

The intergenic HBS1L-MYB region contains MYB enhancer sites and DNA targets for erythroid transcription factors [39]

Fibrosis Foundation.

The precipitates derived from each supernatant were dissolved in Tris buffer (2 mM EDTA/250 mM Tris-HCl) at pH 8.5, reduced with 0.67 M dithiothreitol, alkylated with 1.4 M iodoacetamide and digested with trypsin