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While PON2 and PON3 are restricted to intracellular compartments, PON1 protein is predominantly secreted and found in circulation [50]

Thus, while GSH was discovered more than a century ago 26 , our understanding of its physiological contributions remains incomplete

The term comes from two Japanese components: : rich, deep flavour koku : taste mi Kokumi is usually translated as rich taste, full flavour, or mouthfulness, meaning a sensation of fullness in the mouth

This oxidative reaction occurs spontaneously in the presence of oxygen

In the preliminary screening phase, the standard battery of genotoxicity tests might be unable to identify tissue-specific carcinogens, if the test system lacks the enzymes needed to form the toxic metabolite, and certainly does not provide any information on the possible species specificity of the test compound (Brambilla and Martelli 2004