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Statistical analysis All data were obtained from in vitro experiments in 48 or 96 well plates, with each individual well considered a pseudo-biological replicate

Liver tissue was analyzed for fibrosis and inflammation markers by immunohistochemistry, qPCR and western blotting

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APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

This divergence implies that, despite some overlap in gene regulation, SZ is characterized by unique epigenetic pathways influencing neurotransmitter systems