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At the physiological level, ROS can be used as signaling molecules to participate in cell signaling, regulating cell growth, differentiation and survival (Yang Y

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Also, as discussed above and in the following sections, GPx-1 can regulate apoptogen-mediated signaling in apoptosis (404), alter the activation of NFB (205, 224), and modulate Akt pathways (154, 351) to affect cellular proliferation and survival, suggesting that GPx-1 may have pleiotropic effects on apoptotic susceptibility